The only new bit of information given is the fact there will be over 100 fictitious in-game websites to access from Liberty City's computers, one of which is LibertyCityPolice.com. The other interesting point was Dan Houser talking about his favourite mission in GTA IV.
You can read the full article if you're interested, but apart from the aforementioned snippets there's nothing new.
players are tasked with assassinating a character who’s laid up in the hospital. How gamers achieve this goal is completely up to them, whether they decide to quietly sneak in through a window, boisterously bust through the front door guns blazin’ or don scrubs and simply turn off the mark’s life support.
"We’re giving the player choices without ramming it down their throats," said Houser. "They even have a choice at the key moment in the whole story. I don’t want to go into too much detail about it, but I think putting that into the hands of the player is very fun."